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This latter phenomenon is noted most dramatically in the regulation of water permeability of terminal nephron segments by the antidiuretic hormone ADH. Krogh A, Lindberg AL, Schmidt-Nielson B. General theory and application to red cell. Dick Mammalian Cell Water. Kidney International Volume 22, Issue 5 , November , Pages While it might be considered more reasonable to assume that the w i formed a right-skewed distribution such as a random walk with a first traversal, a description in terms of a mean and standard deviation is about all that one can obtain from experimental data of this sort, and, since no systematic difference between the data and the Gaussian model could be observed for the transient phase, the Gaussian function was considered adequate. A different model, the dead-end pore model, was used for sodium because analysis of the sodium data using the parallel-pathway model gave poor fits of model to data in 8 out of 10 experiments, giving values for A d l which were much larger than the expected extracellular volume and suggesting that sodium had entered the cells.
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

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PITPs were also isolated independently by two separate efforts purifying cytosolic factors that were required for G protein-mediated PLC activation , and ATP-dependent priming of exocytic vesicles This, together with the identification of pleckstrin homology domains , as protein modules that directly bind phosphoinositides , , , exposed the side of phosphoinositides as membrane-bound regulatory molecules as opposed to just being precursors of the two messengers Ins 1,4,5 P 3 and DG. Uduak Okomo, Martin M Meremikwu,.
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